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Asbestos Exposure Significant exposure to any type of asbestos will increase the risk of lung cancer, mesothelioma and nonmalignant lung and pleural disorders, including asbestosis, pleural plaques, pleural thickening, and pleural effusions. This conclusion is based on observations of these diseases in groups of workers with cumulative exposures ranging from about 5 to 1,200 fiber-year/mL. Such exposures would result from 40 years of occupational exposure to air concentrations of 0.125 to 30 fiber/mL. See Detecting Asbestos, for typical levels of concentration. The conclusion is supported by results from animal and mechanistic studies. Asbestos as a cause of mesothelioma was discovered in connection with occupational exposure to the mineral. Asbestos miners, factory workers, shipyard workers and construction workers were the most likely to contract the deadly disease and amongst the first victims. Mesothelioma is a latent disease that can take anywhere from 30 to 40 years to become symptomatic. A number of cases of mesothelioma where therefore reported within similar windows of time, displaying similar occupational backgrounds. Establishing the link back to asbestos (which was already linked to a number of aforementioned diseases) was a relatively simple task.Although other causes of mesothelioma have not been ruled out, asbestos exposure is the only known cause thus far. Health Risks of Asbestos Exposure Chronic exposure to asbestos may increase the risk of lung cancer, mesothelioma, and nonmalignant lung and pleural disorders. Evidence in humans comes from epidemiologic studies as well as numerous studies of workers exposed to asbestos in a variety of occupational settings. Tremolite asbestos exposure has been associated with an increased incidence of disease in vermiculite miners and millers from Libby, Montana. This evidence is supported by reports of increased incidences of nonmalignant respiratory diseases, lung cancer, and mesothelioma in villages in various regions of the world that have traditionally used tremolite-asbestos whitewashes in homes or have high surface deposits of tremolite asbestos and by results from animal studies. Risk Factors Various factors determine how exposure to asbestos affects an individual: Exposure concentration - what was the concentration of asbestos fibers? Exposure duration - how long did the exposure time period last? Exposure frequency - how often during that time period was the person exposed? Size, shape and chemical makeup of asbestos fibers: Long and thin fibers are expected to reach the lower airways and alveolar regions of the lung, to be retained in the lung longer, and to be more toxic than short and wide fibers or particles. Wide particles are expected to be deposited in the upper respiratory tract and not to reach the lung and pleura, the sites of asbestos-induced toxicity. Short, thin fibers, however, may also play a role in asbestos pathogenesis. Fibers of amphibole asbestos such as tremolite asbestos, actinolite asbestos, and crocidolite asbestos are retained longer in the lower respiratory tract than chrysotile fibers of similar dimension. Individual risk factors, such as a person's history of tobacco use (smoking) and other pre-existing lung disease, etc. Cigarette smoke and asbestos together significantly increase your chances of getting lung cancer. Therefore, if you have been exposed to asbestos you should stop smoking. This may be the most important action that you can take to improve your health and decrease your risk of cancer. Source: Agency for Toxic Substances and Disease Registry, www.atsdr.cdc.gov/asbestos